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學(xué)習(xí)快評丨qibao666888　　研?(yan)究??(jiu)團??(tuan)隊??(dui)通??(tong)過??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技?(ji)術(shù)??(shu)??，在??(zai)實??(shi)驗?(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細??(xi)胞??(bao)中?(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因?(yin)??。?失??(shi)去??(qu)這??(zhe)個??(ge)“車??(che)速??(su)控?(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件?(jian)”的??(de)細??(xi)胞??(bao)隨??(sui)之??(zhi)陷?(xian)入??(ru)混??(hun)亂??(luan)??，負??(fu)責??(ze)抑??(yi)制??(zhi)過?(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶?(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比?(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個??(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會??(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時??(shi)徹??(che)底??(di)釋?(shi)放??(fang)NF-κB信??(xin)號??(hao)通??(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等?(deng)炎??(yan)癥??(zheng)因??(yin)子?(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如?(ru)同??(tong)自??(zi)動??(dong)駕??(jia)駛??(shi)汽?(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時??(shi)進??(jin)行??(xing)加??(jia)速??(su)??，會??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴??(yan)重??(zhong)破??(po)壞??(huai)??。。