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學習快評丨qibao666888　　研??(yan)究??(jiu)團??(tuan)隊??(dui)通??(tong)過??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術??(shu)??，在??(zai)實??(shi)驗??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源?(yuan)小??(xiao)膠??(jiao)質??(zhi)細?(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)??。??失?(shi)去??(qu)這??(zhe)個??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件?(jian)”的??(de)細??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂?(luan)??，負??(fu)責??(ze)抑??(yi)制?(zhi)過??(guo)度??(du)反??(fan)應??(ying)的??(de)p21蛋??(dan)白??(bai)產??(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的?(de)關??(guan)鍵??(jian)制??(zhi)動??(dong)環(huán)?(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過?(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個??(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關??(guan)鍵??(jian)分??(fen)子?(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會??(hui)在??(zai)小??(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時??(shi)徹??(che)底??(di)釋??(shi)放??(fang)NF-κB信??(xin)號??(hao)通?(tong)路??(lu)??，繼??(ji)而??(er)引?(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎?(yan)癥??(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同??(tong)自??(zi)動??(dong)駕??(jia)駛??(shi)汽?(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時??(shi)進??(jin)行??(xing)加??(jia)速??(su)??，會?(hui)橫?(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴??(yan)重??(zhong)破??(po)壞??(huai)???！　　败??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)”失??(shi)靈??(ling)引??(yin)發(fā)??(fa)的??(de)災?(zai)難??(nan)。