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學習快評丨qibao666888　　中??(zhong)新??(xin)網(wǎng)??(wang)北??(bei)京??(jing)3月??(yue)26日??(ri)電??(dian) 如?(ru)果??(guo)把??(ba)大??(da)腦??(nao)比??(bi)作?(zuo)處??(chu)于??(yu)精??(jing)密??(mi)運?(yun)轉?(zhuan)中??(zhong)的??(de)自??(zi)動??(dong)駕??(jia)駛??(shi)汽?(qi)車??(che)??，小??(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)就??(jiu)像??(xiang)是??(shi)車??(che)上??(shang)關??(guan)鍵??(jian)的??(de)“智??(zhi)能??(neng)車??(che)載?(zai)維??(wei)保??(bao)系??(xi)統(tǒng)??(tong)”?。??當??(dang)其??(qi)中??(zhong)的??(de)核??(he)心??(xin)原??(yuan)件??(jian)——MEF2C基??(ji)因?(yin)出??(chu)現(xiàn)??(xian)故??(gu)障??(zhang)時??(shi)??，原??(yuan)本??(ben)的??(de)保??(bao)護??(hu)機??(ji)制??(zhi)就??(jiu)會??(hui)陷??(xian)入??(ru)混??(hun)亂??(luan)??，如??(ru)同??(tong)汽??(qi)車??(che)的??(de)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)??，會??(hui)在??(zai)加??(jia)速??(su)時??(shi)失??(shi)控??(kong)、速??(su)度??(du)飆??(biao)升??(sheng)?。此?(ci)時??(shi)小??(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)切??(qie)換??(huan)到??(dao)“狂??(kuang)飆??(biao)”模??(mo)式??(shi)??，引??(yin)發(fā)??(fa)神??(shen)經(jīng)?(jing)炎??(yan)癥??(zheng)??，這??(zhe)便??(bian)是??(shi)自??(zi)閉??(bi)癥??(zheng)、阿??(e)爾??(er)茨??(ci)海??(hai)默??(mo)病??(bing)等??(deng)腦??(nao)疾??(ji)病?(bing)的??(de)重?(zhong)要??(yao)成??(cheng)因??(yin)??！　⊙??(yan)究??(jiu)團?(tuan)隊??(dui)通??(tong)過??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術?(shu)??，在??(zai)實??(shi)驗??(yan)室??(shi)培?(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小?(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)??。??失??(shi)去??(qu)這??(zhe)個??(ge)“車??(che)速?(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的??(de)細??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負??(fu)責??(ze)抑??(yi)制??(zhi)過??(guo)度?(du)反??(fan)應??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)?(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該?(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異?(yi)常??(chang)活??(huo)躍?(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的?(de)關??(guan)鍵??(jian)制??(zhi)動??(dong)環(huán)??(huan)節(jié)??(jie)失?(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活?(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個??(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會??(hui)在??(zai)小??(xiao)膠??(jiao)質?(zhi)細??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時??(shi)徹??(che)底??(di)釋??(shi)放??(fang)NF-κB信??(xin)號??(hao)通??(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如?(ru)同??(tong)自??(zi)動??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時??(shi)進??(jin)行??(xing)加?(jia)速??(su)??，會??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴??(yan)重??(zhong)破?(po)壞??(huai)??。。