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學(xué)習(xí)快評(píng)丨qibao666888　　研??(yan)究??(jiu)團(tuán)??(tuan)隊(duì)??(dui)通??(tong)過??(guo)基?(ji)因??(yin)編??(bian)輯?(ji)技??(ji)術(shù)??(shu)??，在??(zai)實(shí)??(shi)驗(yàn)??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)??。??失??(shi)去??(qu)這??(zhe)個(gè)??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的??(de)細(xì)??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂?(luan)??，負(fù)??(fu)責(zé)??(ze)抑??(yi)制??(zhi)過??(guo)度??(du)反??(fan)應(yīng)??(ying)的?(de)p21蛋?(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活?(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速?(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動(dòng)??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋?(dan)白??(bai)??。這?(zhe)個(gè)??(ge)如??(ru)同?(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就?(jiu)會(huì)??(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時(shí)??(shi)徹??(che)底??(di)釋?(shi)放??(fang)NF-κB信??(xin)號(hào)??(hao)通??(tong)路??(lu)??，繼?(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因?(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同??(tong)自?(zi)動(dòng)?(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時(shí)??(shi)進(jìn)??(jin)行??(xing)加??(jia)速?(su)??，會(huì)??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)??。　　在??(zai)丁??(ding)勝??(sheng)看??(kan)來??(lai)??，過??(guo)去??(qu)30年?(nian)??，神??(shen)經(jīng)??(jing)疾??(ji)病??(bing)藥?(yao)物??(wu)研??(yan)發(fā)?(fa)就?(jiu)像??(xiang)在??(zai)黑??(hei)暗??(an)中??(zhong)用??(yong)獵??(lie)槍??(qiang)打??(da)靶??(ba)??，“而??(er)我??(wo)們??(men)的??(de)發(fā)??(fa)現(xiàn)??(xian)是?(shi)為??(wei)這??(zhe)把??(ba)獵??(lie)槍??(qiang)提??(ti)供??(gong)了??(le)紅??(hong)外??(wai)瞄??(miao)準(zhǔn)??(zhun)鏡??(jing)??。?CDK2是??(shi)精?(jing)確??(que)到?(dao)分??(fen)子??(zi)坐??(zuo)標(biāo)?(biao)的??(de)治?(zhi)療??(liao)靶??(ba)點(diǎn)??(dian)??，藥??(yao)物??(wu)小??(xiao)分??(fen)子??(zi)BMS265246則??(ze)是??(shi)為??(wei)此?(ci)定?(ding)制??(zhi)的??(de)子??(zi)彈??(dan)”??。。