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學(xué)習(xí)快評丨qibao666888　　研??(yan)究??(jiu)團(tuán)??(tuan)隊??(dui)培??(pei)育?(yu)了??(le)具?(ju)有??(you)自??(zi)閉??(bi)癥??(zheng)樣?(yang)癥??(zheng)狀??(zhuang)的??(de)MEF2C缺??(que)陷??(xian)小??(xiao)鼠??(shu)??。??這?(zhe)些??(xie)小??(xiao)鼠??(shu)不??(bu)僅??(jin)表??(biao)現(xiàn)?(xian)出??(chu)嚴(yán)??(yan)重??(zhong)的??(de)社??(she)交?(jiao)障??(zhang)礙??(ai)??，在??(zai)水??(shui)迷??(mi)宮?(gong)測??(ce)試??(shi)中??(zhong)也??(ye)頻??(pin)頻??(pin)迷??(mi)失??(shi)方??(fang)向??(xiang)??。經(jīng)??(jing)過??(guo)8周?(zhou)使??(shi)用??(yong)BMS265246治??(zhi)療??(liao)??，這??(zhe)群秘(qun)小??(xiao)鼠?(shu)腦??(nao)部??(bu)的??(de)炎??(yan)癥??(zheng)因??(yin)子??(zi)風(fēng)??(feng)暴??(bao)消??(xiao)退??(tui)??，開??(kai)始??(shi)主??(zhu)動??(dong)嗅??(xiu)探??(tan)同??(tong)伴??(ban)??，尋?(xun)找??(zhao)水??(shui)迷??(mi)宮??(gong)平??(ping)臺?(tai)的??(de)速??(su)度??(du)顯??(xian)著??(zhu)提?(ti)升?(sheng)??。實??(shi)驗??(yan)顯??(xian)示?(shi)??，藥??(yao)物??(wu)對??(dui)小??(xiao)鼠??(shu)沒??(mei)有??(you)造??(zao)成?(cheng)體??(ti)重??(zhong)減??(jian)輕??(qing)、脫??(tuo)發(fā)??(fa)、血??(xue)液??(ye)學(xué)??(xue)毒??(du)性??(xing)等??(deng)損??(sun)傷??(shang)???！　⊙??(yan)究??(jiu)團(tuán)??(tuan)隊??(dui)通??(tong)過??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實??(shi)驗??(yan)室??(shi)培??(pei)養(yǎng)?(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠?(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除?(chu)MEF2C基??(ji)因??(yin)??。??失?(shi)去??(qu)這?(zhe)個??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)?(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的?(de)細(xì)??(xi)胞??(bao)隨?(sui)之??(zhi)陷?(xian)入??(ru)混??(hun)亂??(luan)??，負(fù)??(fu)責(zé)??(ze)抑??(yi)制??(zhi)過??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳??(rui)減?(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激?(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的?(de)關(guān)??(guan)鍵??(jian)制??(zhi)動??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個??(ge)如??(ru)同??(tong)汽?(qi)車?(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子??(zi)一?(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會?(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時??(shi)徹??(che)底??(di)釋?(shi)放??(fang)NF-κB信??(xin)號??(hao)通??(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎秘(yan)癥??(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模?(mo)爆??(bao)發(fā)?(fa)??，如??(ru)同??(tong)自?(zi)動??(dong)駕??(jia)駛??(shi)汽?(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時??(shi)進(jìn)??(jin)行??(xing)加??(jia)速??(su)??，會??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)??。。